Adrenal steroid hormones stimulate hepatic gluconeogenesis when administered in vivo or when incubated with liver slices in vitro. The steroids also cause increased activity of the liver glutamic pyruvic transaminase (LGPT), and it has been postulated that this is the mechanism through which the hormones alter carbohydrate metabolism. To test this hypothesis, the effect of adrenal steroids on carbohydrate synthesis in liver slices from pyridoxine-deficient rats was determined since pyridoxal phosphate is coenzyme for the LGPT. Effect of the hormones on gluconeogenesis in pyridoxine-deficient liver tissue was equal to that observed previously in normal rat liver and was greater than that which occurred in liver of pair-weighed controls. These findings suggest that increased carbohydrate formation which is induced by adrenocortical hormones may be unrelated to the effect of the steroids on LGPT activity (Endocrinology74: 742, 1964)
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Albert B. Eisenstein (1964) studied this question.