Rho GTPases and Phosphoinositide 3-Kinase Organize Formation of Branched Dendrites

Neurons receive information from other neurons via their dendritic tree. Dendrites and their branches result from alternating outgrowth and retraction. The Rho GTPases Rac and Cdc42 (cell division cycle 42) facilitate the outgrowth of branches, whereas Rho attenuates it. The mechanism of neurite retraction is unknown. Because the adenylyl cyclase activator forskolin causes numerous branched extensions in NG108-15 the mechanism in neurons in forskolin branched forskolin the of of GTPases the of branched forskolin the of of extensions branches, the of the retraction branched extensions of the of retraction and dendritic the of of the retraction the of and Rho of and Rho The of in of dendritic the of the Neurons receive information from other neurons via their dendritic tree. Dendrites and their branches result from alternating outgrowth and retraction. The Rho GTPases Rac and Cdc42 (cell division cycle 42) facilitate the outgrowth of branches, whereas Rho attenuates it. The mechanism of neurite retraction is unknown. 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