Key result
The PKC activator OAG increased neuronal excitability by amplifying the persistent Na+ current-dependent subthreshold depolarisation, despite reducing the maximal transient Na+ current peak amplitude by 30%.
Population
Rat neocortical pyramidal neurones (dissociated and in slices)
Comparison
1-oleoyl-2-acetyl-sn-glycerol added to… vs Control conditions
Design
Preclinical
Authors
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PKC effects on persistent Na+ current may drive excitability changes overlooked by peak measures; extends cellular models but leaves open in vivo relevance.
PKC activation by OAG increases neuronal excitability by amplifying persistent Na+ current-dependent subthreshold depolarisation, overriding the inhibition of transient Na+ current peak amplitude.
Franceschetti et al. (2000) studied Rat neocortical pyramidal neurones. 1-oleoyl-2-acetyl-sn-glycerol (OAG) vs. Control conditions was evaluated on TTX-sensitive Na+ currents and neuronal excitability. The PKC activator OAG increased neuronal excitability by amplifying the persistent Na+ current-dependent subthreshold depolarisation, despite reducing the maximal transient Na+ current peak amplitude by 30%.
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