Key result
Subsystolic occlusion of locomotor muscles during exercise demonstrated that increased pulmonary artery pressure contributes to DL CO via heightened capillary recruitment (D M).
Why the study?
It was unclear how pulmonary artery pressure impacts the pulmonary microcirculatory adjustments that comprise DL CO, specifically V c and D M.
Does subsystolic occlusion of locomotor muscles during exercise alter DL CO, Vc, and DM in humans?
Does subsystolic occlusion of locomotor muscles during exercise alter DL CO, Vc, and DM in humans?
Increases in pulmonary artery pressure during exercise contribute to DL CO via heightened capillary recruitment (DM).
Answers are grounded in this paper and cite their sources.
Pulmonary pressure may influence exercise DLCO; hypothesis-generating for cardiopulmonary assessment and should not yet change practice.
Pulmonary artery pressure contributes to DL CO recruitment during exercise. However, it is unclear how pulmonary artery pressure impacts the pulmonary microcirculatory adjustments that comprise DL CO , namely V c and D M . Using subsystolic occlusion of the locomotor muscles during exercise to induce increases in pulmonary artery pressure, without changes in cardiac output or metabolic demand, we demonstrate that pulmonary artery pressure contributes to DL CO during exercise via heightened capillary recruitment (D M ).
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D’Souza et al. (2025) studied this question. Subsystolic occlusion of locomotor muscles during exercise was evaluated on DL CO, V c, and D M. Subsystolic occlusion of locomotor muscles during exercise demonstrated that increased pulmonary artery pressure contributes to DL CO via heightened capillary recruitment (D M).
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