We investigated to evaluate efficacy of exercise on cognition in very older adults with MCI andto analyze the effects of a exercise program on peripheral BDNF levels. The participants were 102 patients with MCI assigned randomly to exercise program therapy group and a control group. 121 participant (75∼91 years old) were randomized to a sequence of 48 session of exercise training. The main goal was to analyze the effects of a 24-week program on peripheral BDNF levels in very elderly with MCI. Cognitive functions were assessed by MMSE, GDS, BNT, block design, semantic fluency and matrix reasoning prior to and after the intervention. The study results showed a significant improvement of BDNF (p<.05) peripheral concentrations. Cognitive functions also presented significant (p<.05) improvements for trained group; MMSE(1.83), GDS(0.71), BNT(3.11), block design(12.46), semantic fluency(1.23) and matrix reasoning(3.21). Exercise training is an effective method for impovement of BDNF level and cognition in very older MCI.
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Kyung‐Phil Kwak (2015) studied this question.