Key result
In patients with systolic heart failure and altered myocardial sympathetic innervation, the presence of left ventricular mechanical dyssynchrony by gated SPECT did not significantly increase the composite outcome of death or ICD shock (58.8% vs 40.0%, p=0.624).
Why the study?
Does the presence of left ventricular mechanical dyssynchrony by gated SPECT predict mortality or adverse cardiac events in systolic heart failure patients with abnormal I-123 mIBG uptake?
Cohort (n=22)
No
Does the presence of left ventricular mechanical dyssynchrony by gated SPECT predict mortality or adverse cardiac events in systolic heart failure patients with abnormal I-123 mIBG uptake?
In a small pilot study of systolic heart failure patients with altered myocardial sympathetic innervation, the addition of SPECT-based left ventricular mechanical dyssynchrony did not significantly improve the prediction of mortality or adverse cardiac events.
Mechanical dyssynchrony adds no prognostic value here; leaves open utility of combined imaging for risk stratification in systolic HF.
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Mohammed et al. (2016) conducted a cohort in Systolic heart failure with altered myocardial sympathetic innervation (n=22). Left ventricular mechanical dyssynchrony (LVMD) by gated SPECT vs. Absence of LVMD was evaluated on Death and/or ICD shock (p=0.624). In patients with systolic heart failure and altered myocardial sympathetic innervation, the presence of left ventricular mechanical dyssynchrony by gated SPECT did not significantly increase the composite outcome of death or ICD shock (58.8% vs 40.0%, p=0.624).
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