The biochemical effects of experimental renal insufficiency produced by bilateral nephrectomy on perilymph were studied. Rats were used for the experiments; measurements were carried out at various intervals after nephrectomy. Statistically significant changes in perilymph (osmolality, Na, K, Cl, and urea), and serum (osmolality, urea and creatinine) were found. These findings represent a marked labyrinth alteration, and may partly explain the pathophysiology of labyrinthine disturbances in chronic renal disease.
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Urquiza et al. (1986) studied this question.
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