April 4, 2006CirculationOpen Access

Role of p90 Ribosomal S6 Kinase–Mediated Prorenin-Converting Enzyme in Ischemic and Diabetic Myocardium

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Population

Transgenic mice with cardiac-specific overexpression of wild-type p90 ribosomal S6 kinase and a…

Comparison

Ischemia/reperfusion with or without ACE-I or… vs Non-Tg littermate controls; untreated mice.

Design

Preclinical

Authors

SISeigo ItohJuntendo University BDBo DingNational University of Defense Technology TSTetsuro ShishidoYamagata City Hospital Saiseikan

Discussion

Member takes

Implication

Suggests p90RSK-dependent RAS benefit in diabetic I/R models; leaves open translation to human diabetic cardiomyopathy.

Structured PICO

Population

Transgenic mice with cardiac-specific overexpression of wild-type p90 ribosomal S6 kinase (WT-p90RSK-Tg) and a dominant-negative form (DN-p90RSK-Tg), and non-Tg littermate controls.

Intervention

Ischemia/reperfusion with or without ACE-I (captopril) or ARB (olmesartan); streptozotocin-induced hyperglycemia.

Comparator

Non-Tg littermate controls; untreated mice.

Outcome

Recovery of cardiac function and infarct size after ischemia/reperfusion; prorenin-converting enzyme (PRECE) induction.surrogate

p90RSK plays a critical role in hyperglycemia-mediated myocardial PRECE induction, providing a potential molecular mechanism for RAS augmentation in diabetic hearts and a therapeutic target for diabetic cardiomyopathy.

Cite This Study

Itoh et al. (2006) studied this question.

synapsesocial.com/papers/6a8b91c2c12eaf65c8b20a63 https://doi.org/10.1161/circulationaha.105.578278

Topics

Cardiomyopathy

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Role of p90 Ribosomal S6 Kinase–Mediated Prorenin-Converting Enzyme in Ischemic and Diabetic Myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Role of p90 Ribosomal S6 Kinase–Mediated Prorenin-Converting Enzyme in Ischemic and Diabetic Myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider