Population
Platelets from rats with spontaneous or streptozotocin-induced diabetes
Comparison
Addition of ADP (10 microM) vs Platelets from corresponding non-diabetic…
Design
Preclinical
Authors
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Enhanced fibrinogen binding may underlie diabetic platelet hyperreactivity; hypothesis-generating in animals and requires human validation.
The hypersensitivity to ADP observed in platelets from diabetic rats is associated with enhanced early fibrinogen binding, which appears to be driven by the diabetic state itself rather than insulin treatment.
Winocour et al. (1992) studied this question.
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