Key result
Presentation SIRS linked to ~2.7-fold higher odds of early coronary lesions in Kawasaki disease.
Why the study?
Inflammatory cytokines are elevated in Kawasaki disease patients who develop coronary artery lesions, but whether systemic inflammatory response syndrome as an index of hypercytokinemia relates to lesion formation remained unclear.
Does systemic inflammatory response syndrome (SIRS) predict coronary artery lesions in patients with Kawasaki disease?
Cohort (n=277)
No
Does systemic inflammatory response syndrome (SIRS) predict coronary artery lesions in patients with Kawasaki disease?
SIRS can be a risk factor for coronary artery lesions in the acute phase of Kawasaki disease.
SIRS may flag higher-risk Kawasaki disease cases for closer coronary surveillance; leaves open whether it guides lesion-preventing interventions.
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Tomobe et al. (2019) conducted a cohort in Kawasaki Disease (n=277). Systemic Inflammatory Response Syndrome (SIRS) vs. Non-SIRS was evaluated on Incidence of coronary artery lesion (CAL) formation at week 1 (OR 2.7, 95% CI 1.03-7.23, p=0.04). Systemic inflammatory response syndrome (SIRS) at presentation was an independent risk factor for coronary artery lesion formation at week 1 in pediatric patients with Kawasaki disease (17.7% vs 7.8%; OR 2.7).
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