Aquayamycin was found to be a strong inhibitor of tyrosine hydroxylase. It inhibits tyrosine hydroxylase by 50 % at 3.7×10-7M. The inhibition is noncompetitive with tyrosine. The inhibition by 4×10-7 Maquayamycin increases when the concentration of 2-amino-4-hydroxy-6, 7-dimethyltetrahydropteridine is increased from 2×10-4M to 1×10-3M. The inhibition of tyrosine hydroxylase by aquayamycin is reversed by Fe++.
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Ayukawa et al. (1968) studied this question.
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