Why the study?
After ischemic injury, cardiac remodeling involves inflammatory and fibrotic responses regulated by microRNAs, warranting an updated summary of their functional interactions and clinical applications.
This review highlights the emerging role of microRNAs in modulating post-myocardial infarction inflammation and fibrosis, pointing toward potential clinical applications.
miRNA regulation of post-MI inflammation and fibrosis remains exploratory; review leaves open clinical translation of targeted therapies.
After an ischemic injury, the heart undergoes a complex process of structural and functional remodeling that involves several steps, including inflammatory and fibrotic responses. In this review, we are focusing on the contribution of microRNAs in the regulation of inflammation and fibrosis after myocardial infarction. We summarize the most updated studies exploring the interactions between microRNAs and key regulators of inflammation and fibroblast activation and we discuss the recent discoveries, including clinical applications, in these rapidly advancing fields.
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Varzideh et al. (2022) studied this question.
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