Selenocysteine (Sec), the 21st amino acid, is a component of a variety of proteins in all lineages of life, and the greater acidity of selenols compared to thiols provides Sec with unique chemical properties. By using 77Se NMR spectroscopy the pKa of Sec residues in a protein could be measured at atomic resolution. This information can be used to predict chemical reactions.
No takes yet. Share an insight, caveat, or question.
Mobli et al. (2011) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: