Why the study?
Do cardiac troponins offer better sensitivity and specificity than CK-MB for diagnosing perioperative myocardial infarction in surgical patients?
Population
High-risk patients undergoing either cardiac or noncardiac surgery
Comparison
Cardiac troponins (troponin-I and troponin-T) vs Creatine kinase isoenzymes (CK-MB)
Design
Review
Authors
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Troponins may aid perioperative MI diagnosis but should not yet replace CK-MB; leaves open need for definitive trials in high-risk surgical patients.
Do cardiac troponins offer better sensitivity and specificity than CK-MB for diagnosing perioperative myocardial infarction in surgical patients?
Cardiac troponins are promising biomarkers for diagnosing perioperative myocardial infarction due to their prolonged diagnostic window and potential for higher specificity than CK-MB, though further definitive studies are needed.
Dennis T. Mangano (1994) studied this question.