One of the largest contributors to chlorinated solvent waste in medicinal chemistry is chromatography. A set of “drug-like” compounds was employed to compare the relative eluting strengths of greener solvent systems. Disclosed herein is an experimentally-derived solvent selection guide to aid chemists in choosing greener solvents for chromatographic purification, with a particular focus on reducing dichloromethane usage.
No takes yet. Share an insight, caveat, or question.
Taygerly et al. (2012) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: