What question did this study set out to answer?

To determine the incidence of positive urinary nuclear matrix protein 22 (NMP22) levels in patients with renal cell carcinoma compared to non-cancer controls.

February 1, 2005Scandinavian Journal of Urology and Nephrology

Urinary nuclear matrix protein 22 for diagnosis of renal cell carcinoma

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Authors

KKKerem KayaIstanbul Technical University SAS. AyanKaradeniz Technical University GGGökhan GökçeSivas Cumhuriyet Üniversitesi

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Implication

Case-control study reveals elevated urinary nuclear matrix protein 22 in renal cell carcinoma, highlighting potential diagnostic utility beyond bladder cancer.

Key Points

To determine the incidence of positive urinary nuclear matrix protein 22 (NMP22) levels in patients with renal cell carcinoma compared to non-cancer controls.
Measured preoperative urinary NMP22 levels in 41 patients with CT-detected solid renal masses scheduled for radical nephrectomy, confirming renal cell carcinoma in 38 cases after 3 non-RCC exclusions.
Evaluated 30 patients with kidney stones and simple renal cysts as a control group using an established NMP22 cut-off threshold of ≥10 U/ml.
Urinary NMP22 levels were significantly higher in patients with renal cell carcinoma than in controls, with positive tests (≥10 U/ml) occurring in 60.5% (23/38) of cancer cases versus 13.3% (4/30) of controls.
Urinary NMP22 values increased alongside pathologic tumor stage, though this trend was not statistically significant, and values demonstrated no correlation with tumor grade or tumor burden.

Cite This Study

Kaya et al. (2005) studied this question.

synapsesocial.com/papers/6a8bac92a368e523f2fb392e https://doi.org/10.1080/00365590410002500

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Implication

Case-control study reveals elevated urinary nuclear matrix protein 22 in renal cell carcinoma, highlighting potential diagnostic utility beyond bladder cancer.

Urinary nuclear matrix protein 22 for diagnosis of renal cell carcinoma

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Implication

Key Points

Cite This Study

Urinary nuclear matrix protein 22 for diagnosis of renal cell carcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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