With the discovery of insulin in 1921, many physicians thought that diabetes mellitus would become an easily treatable disease. This was not an unreasonable assumption, because other states of hormonal deficiency, including hypothyroidism, hypoadrenalism, and isolated growth hormone deficiency, have been "cured" with the discovery and availability of the missing hormone. In contrast, the discovery of insulin marked the beginning rather than the end of a major effort by many investigators to provide insulin to diabetic patients in a way that would correct the metabolic abnormalities of diabetes mellitus.Why has the method of insulin delivery become a major focus . . .
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Schade et al. (1985) studied this question.
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