What is Good’s syndrome? Immunological abnormalities in patients with thymoma

Good's syndrome (thymoma with immunodeficiency) is a rare cause of combined B and T cell immunodeficiency in adults. The clinical characteristics of Good's syndrome are increased susceptibility to bacterial infections with encapsulated organisms and opportunistic viral and fungal infections. The most consistent immunological abnormalities are hypogammaglobulinaemia and reduced or absent B cells. This disorder should be treated by resection of the thymoma and immunoglobulin replacement to maintain adequate trough IgG values.