Preoperative NYHA class III/IV symptoms in severe aortic regurgitation predicted worse 10-year postoperative survival versus class I/II symptoms (45% vs 78%; adjusted HR 1.81, p=0.0091).
Cohort (n=289)
Hazard Ratio: 1.81
Absolute Event Rate: 45% vs 78%
p-value: p=0.0091
OBJECTIVES: We sought to determine the independent effect of preoperative symptoms on survival after surgical correction of aortic regurgitation (AR). BACKGROUND: Aortic valve replacement for severe AR is recommended after New York Heart Association functional class III or IV symptoms develop. However, whether severe preoperative symptoms have a negative influence on postoperative survival remains controversial. METHODS: Preoperative characteristics and postoperative survival in 161 patients with functional class I or II symptoms (group 1) were compared with those in 128 patients with class III or IV symptoms (group 2) undergoing surgical repair of severe isolated AR between 1980 and 1989. RESULTS: Compared with group 1, group 2 patients were older (p < 0.0001), were more often female (p = 0.001) and more often had a history of hypertension (p = 0.001), diabetes mellitus (p = 0.029) or myocardial infarction (p = 0.005) and were more likely to require coronary artery bypass graft surgery (p < 0.0001). The operative mortality rate was higher in group 2 (7.8%) than in group 1 (1.2%, p = 0.005), and the 10-year postoperative survival rate was worse (45% +/- 5% group 2 vs. 78% +/- 4% group 1, p < 0.0001). Compared with age- and gender-matched control subjects, long-term postoperative survival was similar to that expected in group 1 (p = 0.14) but significantly worse in group 2 (p < 0.0001). On multivariate analysis, functional class III or IV symptoms were significant independent predictors of operative mortality (adjusted odds ratio 5.5, p = 0.036) and worse long-term postoperative survival (adjusted hazard ratio 1.81, p = 0.0091). CONCLUSIONS: In the setting of severe AR, preoperative functional class III or IV symptoms are independent risk factors for excess immediate and long-term postoperative mortality. The presence of class II symptoms should be a strong incentive to consider immediate surgical correction of severe AR.
Klodas et al. (Tue,) conducted a cohort in Severe aortic regurgitation (n=289). Preoperative NYHA functional class III or IV symptoms vs. Preoperative NYHA functional class I or II symptoms was evaluated on Long-term postoperative survival (HR 1.81, p=0.0091). Preoperative NYHA class III/IV symptoms in severe aortic regurgitation predicted worse 10-year postoperative survival versus class I/II symptoms (45% vs 78%; adjusted HR 1.81, p=0.0091).
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