Answers are grounded in this paper and cite their sources.
Total syntheses of (-)-variabilin and (-)-glycinol have been accomplished, using the catalytic, asymmetric "interrupted" Feist-Bénary reaction (IFB) as the key transformation to introduce both stereogenic centers. A monoquinidine pyrimidinyl ether catalyst affords the IFB products in over 90% ee in both cases. Other key steps include an intramolecular Buchwald-Hartwig coupling and a nickel-catalyzed aryl tosylate reduction.
No takes yet. Share an insight, caveat, or question.
Calter et al. (2011) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: