Within 30 minutes after injecting dl-mevalonate-2-C14 into young rats, the total body non-saponifiable fraction contained 47.6% of the biologically active C14-mevalonate. Time course data suggest that at this time utilization of tracer MVA was essentially complete. Urinary radioactivity accounted for slightly more than one-half of the dose. The metabolism of nonsaponifiable fractions of liver and gut may be related by two processes having similar but reciprocal half times. Kidney tissue was found to contain the greater part of the radioactivity previously associated with carcass nonsaponifiable fractions. A small but consistent amount of label was found in the saponifiable fractions.
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Elwood et al. (1961) studied this question.
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