Two reviews published recently reflect the history of neuropeptide research. One of them1 reports the results of a computer search of the scientific literature since 1966. It found more than a quarter of a million papers published concerning those peptides that now are known to be able to exert some effects on the central nervous system (CNS).
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Kastin et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: