Azide‐ and Alkyne‐Derivatised α‐Amino Acids

With the emergence of the copper‐catalysed Huisgen cycloaddition the use of azide‐ and alkyne‐derivatised α‐amino acids has found widespread use within most chemistry disciplines. Despite a growing interest in these building blocks researchers are struggling to identify the best way for their synthesis. In this review we have compiled available methods for synthesising optically active azide‐ and alkyne‐derivatised α‐amino acids that can be prepared from readily available α‐amino acids. We highlight a number of commonly overlooked problems associated with existing methods and direct attention to unexplored possibilities.