A New Prenylated Flavone from the Leaves of Glycyrrhiza uralensis Cultivated in China

A new prenylated flavone, 6,5′-diprenylluteolin (1), together with three known compounds chrysoeriol (2), kaempferol 3-O-glucoside (3), quercetin 3-O-glucoside (4) was isolated from the leaves of Glycyrrhiza uralensis cultivated in China.The structure of 1 was established on the basis of spectroscopic evidence.The roots of Glycyrrhiza species are one of the most important crude drugs in China and Europe.Many biological activities were reported, such as antimutagenic activity, 1 antitumor promoting activity, 2 antimicrobial activity, 3 and antioxidant activity. 4These activities are reported due to two kinds of main constituents, the saponins and flavonoids.The aerial parts of the plant are scarcely used and always considered as waste products.However, studies on the aerial parts belonging to different species of this genus have highlighted the antimicrobial 5 and anti-HIV 6 properties of their extracts.Recently, in China, the cultivated licorice is serving as the main resource for the exhaustion of the wild