Kalirin is a neuron-specific GDP/GTP exchange factor for Rho subfamily GTP-binding proteins. The major Kalirin transcripts in adult rat brain were identified. Most include a Sec14p-like putative lipid-binding motif followed by nine spectrin-like repeats and a Dbl homology/pleckstrin homology (DH-PH) domain. Kalirin proteins with four different NH2 termini are generated through the use of five different 5′-ends; three of the proteins differ only at the extreme NH2 terminus, and one is truncated because translation is initiated at a methionine in the 5th spectrin repeat. Four different 3′-ends yield Kalirin proteins with additional functional domains. Kalirin-7 (7-kilobase pair mRNA) terminates with a PDZ-binding motif, which in Kalirin-8 is replaced by an SH3 domain. Kalirin-9 contains another pair of DH-PH and SH3 domains. Kalirin-12 additionally encodes a putative Ser/Thr protein kinase. Antisera specific for different COOH termini established Kalirin-7 as the most abundant in cortex, with significant amounts of Kalirin-9 and Kalirin-12; Kalirin-7 was less prevalent in cerebellum and olfactory bulb. Kalirin proteins lacking the Sec14p-like domain and first four spectrin-like repeats were much less prevalent. Form-specific antisera demonstrated that different forms of Kalirin were localized to distinct subcellular regions of cultured neurons. Members of the family of Kalirin proteins may subserve different functions at these different locations. Kalirin is a neuron-specific GDP/GTP exchange factor for Rho subfamily GTP-binding proteins. The major Kalirin transcripts in adult rat brain were identified. Most include a Sec14p-like putative lipid-binding motif followed by nine spectrin-like repeats and a Dbl homology/pleckstrin homology (DH-PH) domain. Kalirin proteins with four different NH2 termini are generated through the use of five different 5′-ends; three of the proteins differ only at the extreme NH2 terminus, and one is truncated because translation is initiated at a methionine in the 5th spectrin repeat. Four different 3′-ends yield Kalirin proteins with additional functional domains. Kalirin-7 (7-kilobase pair mRNA) terminates with a PDZ-binding motif, which in Kalirin-8 is replaced by an SH3 domain. Kalirin-9 contains another pair of DH-PH and SH3 domains. Kalirin-12 additionally encodes a putative Ser/Thr protein kinase. Antisera specific for different COOH termini established Kalirin-7 as the most abundant in cortex, with significant amounts of Kalirin-9 and Kalirin-12; Kalirin-7 was less prevalent in cerebellum and olfactory bulb. Kalirin proteins lacking the Sec14p-like domain and first four spectrin-like repeats were much less prevalent. Form-specific antisera demonstrated that different forms of Kalirin were localized to distinct subcellular regions of cultured neurons. Members of the family of Kalirin proteins may subserve different functions at these different locations. GDP/GTP exchange factors Dbl (deleted in B-cell lymphoma) homology peptidylglycine α-amidating monooxygenase pBluescript PAM-COOH-terminal interactor protein pleckstrin homology rapid amplification of cDNA ends reverse transcription-polymerase chain reaction polyacrylamide gel electrophoresis src homology 3 inducible nitric-oxide synthase nucleotides kilobase pair base pair untranslated region rapid amplification of cDNA ends The Dbl family of GDP/GTP exchange factors (GEFs)1 for small GTP-binding proteins of the Rho subfamily is large and growing (1.Cerione R.A. Zheng Y. Curr. Opin Cell Biol. 1996; 8: 216-222Crossref PubMed Scopus (466) Google Scholar, 2.Whitehead I.P. Campbell S. Rossman K.L. Der C.J. Biochim. Biophys. Acta. 1997; 1332: F1-F23Crossref PubMed Scopus (334) Google Scholar, 3.Kjoller L. Hall A. Exp. Cell Res. 1999; 253: 166-179Crossref PubMed Scopus (344) Google Scholar, 4.Zohn I.M. Campbell S.L. Khosravi-Far R. Rossman K.L. Der C.J. Oncogene. 1998; 17: 1415-1438Crossref PubMed Scopus (320) Google Scholar) (Fig.1). Adjacent DH and PH domains are common to all family members, with various additional domains present in the NH2- and COOH-terminal ends. Dbl and many of the earliest members of this protein family were identified through their oncogenic activity; several were found to be especially prevalent in the nervous system (2.Whitehead I.P. Campbell S. Rossman K.L. Der C.J. Biochim. Biophys. Acta. 1997; 1332: F1-F23Crossref PubMed Scopus (334) Google Scholar). More recently, neuron-specific members of the Dbl family such as Kalirin (see below) and collybistin (5.Kins S. Betz H. Kirsch J. Nat. Neurosci. 2000; 3: 22-29Crossref PubMed Scopus (231) Google Scholar) have been identified through protein-protein interaction screens. Kalirin was identified as a protein interacting with the COOH-terminal cytoplasmic tail of the peptide-processing enzyme peptidylglycine α-amidating monooxygenase (PAM) (6.Alam M.R. Caldwell B.D. Johnson R.C. Darlington D.N. Mains R.E. Eipper B.A. J. Biol. Chem. 1996; 271: 28636-28640Abstract Full Text Full Text PDF PubMed Scopus (73) Google Scholar). Kalirin (Duo) was also identified as an interactor with Huntingtin-associated protein-1 (7.Colomer V. Engelender S. Sharp A.H. Duan K. Cooper J.K. Lanahan A. Lyford G. Worley P. Ross C.A. Hum. Mol. Genet. 1997; 6: 1519-1525Crossref PubMed Scopus (111) Google Scholar) and the inducible form of nitric-oxide synthase (8.Ratovitski E.A. Alam M.R. Quick R.A. McMillan A. Bao C. Hand T.A. Johnson R.C. Mains R.E. Eipper B.A. Lowenstein C.J. J. Biol. Chem. 1999; 274: 993-999Abstract Full Text Full Text PDF PubMed Scopus (104) Google Scholar). Kalirin is found in a large fraction of central nervous system neurons, notably in long projection neurons (9.Alam M.R. Johnson R.C. Darlington D.N. Hand T.A. Mains R.E. Eipper B.A. J. Biol. Chem. 1997; 272: 12667-12675Abstract Full Text Full Text PDF PubMed Scopus (113) Google Scholar). When expressed in pituitary tumor cells, Kalirin increases the length and branching patterns of processes and facilitates regulated secretion (9.Alam M.R. Johnson R.C. Darlington D.N. Hand T.A. Mains R.E. Eipper B.A. J. Biol. Chem. 1997; 272: 12667-12675Abstract Full Text Full Text PDF PubMed Scopus (113) Google Scholar, 10.Mains R.E. Alam M.R. Johnson R.C. Darlington D.N. Back N. Hand T.A. Eipper B.A. J. Biol. Chem. 1999; 274: 2929-2937Abstract Full Text Full Text PDF PubMed Scopus (53) Google Scholar). By forming heterodimers with iNOS and inactivating it, Kalirin restores stimulated secretion to cells in which secretion has been inhibited by induction of iNOS (8.Ratovitski E.A. Alam M.R. Quick R.A. McMillan A. Bao C. Hand T.A. Johnson R.C. Mains R.E. Eipper B.A. Lowenstein C.J. J. Biol. Chem. 1999; 274: 993-999Abstract Full Text Full Text PDF PubMed Scopus (104) Google Scholar). The role of Kalirin in the normal functioning of the nervous system has not yet been explored. The first forms of rat Kalirin identified (called P-CIP10a and -10b) differed only at their 5′-ends, sharing a phospholipid binding motif (11.Aravind L. 1999; Full Text Full Text PDF PubMed Google nine spectrin-like a DH-PH and an SH3 domain (9.Alam M.R. Johnson R.C. Darlington D.N. Hand T.A. Mains R.E. Eipper B.A. J. Biol. Chem. 1997; 272: 12667-12675Abstract Full Text Full Text PDF PubMed Scopus (113) Google Scholar). The of Kalirin P-CIP10a and at the the NH2 (7.Colomer V. Engelender S. Sharp A.H. Duan K. Cooper J.K. Lanahan A. Lyford G. Worley P. Ross C.A. Hum. Mol. Genet. 1997; 6: 1519-1525Crossref PubMed Scopus (111) Google Scholar). Kalirin (Duo) an SH3 with a putative motif (7.Colomer V. Engelender S. Sharp A.H. Duan K. Cooper J.K. Lanahan A. Lyford G. Worley P. Ross C.A. Hum. Mol. Genet. 1997; 6: 1519-1525Crossref PubMed Scopus (111) Google Scholar, P. Johnson R.C. Alam M.R. V. Mains R.E. Eipper B.A. J. Biol. Chem. 2000; Full Text Full Text PDF PubMed Scopus (113) Google Scholar). rat was the of this is to as Kalirin-7 P. Johnson R.C. Alam M.R. V. Mains R.E. Eipper B.A. J. Biol. Chem. 2000; Full Text Full Text PDF PubMed Scopus (113) Google Scholar). P-CIP10a and be to as and to that additional forms of Kalirin to be identified. Kalirin-7 is a major with Kalirin in to When to of rat cortex, to the spectrin-like region of Kalirin proteins in to P. Johnson R.C. Alam M.R. V. Mains R.E. Eipper B.A. J. Biol. Chem. 2000; Full Text Full Text PDF PubMed Scopus (113) Google Scholar). a major protein of was localized to the and the to are to domains not present in Kalirin-7 A. C. K. S. S. A. 1996; PubMed Scopus Google Scholar, R. Zheng H. S. J. 1998; Full Text Full Text PDF PubMed Scopus Google Scholar) the of three forms of and The was to and to and distinct Form-specific cDNA were for and was to and antisera were to the proteins in brain and to the proteins in cultured neurons. rat and was was the amounts of and were by in a gel Eipper B.A. Mains R.E. Mol. PubMed Scopus Google Scholar). electrophoresis and to a the was and The were with cDNA Eipper B.A. Mains R.E. Mol. PubMed Scopus Google that was to the for the Kalirin-8 COOH was by to in to different The to the regions of spectrin domains spectrin domains Kalirin-8 COOH in Kalirin-7 in and in and Kalirin in Kalirin is not expressed in (9.Alam M.R. Johnson R.C. Darlington D.N. Hand T.A. Mains R.E. Eipper B.A. J. Biol. Chem. 1997; 272: 12667-12675Abstract Full Text Full Text PDF PubMed Scopus (113) Google which as a is the of The Kalirin-7 is cDNA was of rat in a for were as The system was for all the cDNA was for in all of reaction was a gel and to for the for and are in a and are of a rat cDNA has been (9.Alam M.R. Johnson R.C. Darlington D.N. Hand T.A. Mains R.E. Eipper B.A. J. Biol. Chem. 1997; 272: 12667-12675Abstract Full Text Full Text PDF PubMed Scopus (113) Google Scholar). with a of in were pBluescript a with of and a that this was as and cDNA of and an additional in of were by this were the The was by with which at in Kalirin and in the gel the the and the first of was to a with an of to the at the (see 3 was the of the in the this was and at in the was to The system was for in proteins were of of in a were by The gel was with and to for was to the of rat Kalirin-9 R.C. Darlington D.N. Hand T.A. Mains R.E. PubMed Scopus Google Scholar). cDNA was of rat and a in a cDNA was for a and a at in Kalirin-8 of Kalirin-7 reaction was for the and a an was and that this Kalirin-8 at another of of (see at and was the as the that a is The Kalirin-9 is The rat Kalirin-12 was identified by rat cDNA with a at an and an the was and that this the of the region of Kalirin-9 and an that in the (see were the system was the of cDNA were to and generated cDNA The Kalirin-12 is antisera to and Kalirin-7 were P. Johnson R.C. Alam M.R. V. Mains R.E. Eipper B.A. J. Biol. Chem. 2000; Full Text Full Text PDF PubMed Scopus (113) Google Scholar). antisera were generated at by with the was generated the of the SH3 domain of Kalirin of Kalirin-9 was generated the the COOH-terminal of rat Kalirin-9 to Kalirin-9 are was generated a the COOH-terminal of rat Kalirin-12 were by and were to with of to and were their to were at a of was the were to their and were adult and were in of and a and with of a were by at for of neurons rat were by established and for P. Johnson R.C. Alam M.R. V. Mains R.E. Eipper B.A. J. Biol. Chem. 2000; Full Text Full Text PDF PubMed Scopus (113) Google Scholar). of in and were with a at of was and were for at The was by at for and with The proteins were by the in of and by and of adult rat specific to different regions of the Kalirin transcripts and a with in to Kalirin spectrin-like domains the DH-PH domains major transcripts of and were at three transcripts and were present at to the COOH of Kalirin-8 to transcripts of and specific for the of Kalirin-7 only to the major transcripts and spectrin-like domains to the major as as to transcripts of and the in has been is that a was not by this specific for the extreme of Kalirin also to a not The of a and not in that this is a of (9.Alam M.R. Johnson R.C. Darlington D.N. Hand T.A. Mains R.E. Eipper B.A. J. Biol. Chem. 1997; 272: 12667-12675Abstract Full Text Full Text PDF PubMed Scopus (113) Google of the transcripts in Kalirin-8 was the first form of Kalirin identified (9.Alam M.R. Johnson R.C. Darlington D.N. Hand T.A. Mains R.E. Eipper B.A. J. Biol. Chem. 1997; 272: 12667-12675Abstract Full Text Full Text PDF PubMed Scopus (113) Google is not an abundant in the The COOH-terminal of Kalirin-7 the of with a in a putative motif, P. Johnson R.C. Alam M.R. V. Mains R.E. Eipper B.A. J. Biol. Chem. 2000; Full Text Full Text PDF PubMed Scopus (113) Google Scholar). to a specific for the of Kalirin-7 the most abundant transcripts and are the only Kalirin transcripts that have this COOH of also demonstrated that the Kalirin-7 protein was expressed to the Kalirin forms P. Johnson R.C. Alam M.R. V. Mains R.E. Eipper B.A. J. Biol. Chem. 2000; Full Text Full Text PDF PubMed Scopus (113) Google and and adult cortex, the Kalirin is the most prevalent form a at the Kalirin and an at the Kalirin-7 3 a P. Johnson R.C. Alam M.R. V. Mains R.E. Eipper B.A. J. Biol. Chem. 2000; Full Text Full Text PDF PubMed Scopus (113) Google Scholar). with the that the Kalirin a and was not the of the a rat cDNA with a to spectrin-like domains of Kalirin were to Kalirin-7 of distinct Kalirin-7 of this 3 of and this not include an methionine a with the 3 the were a be The first methionine at the of the spectrin-like domain of Kalirin-7 and the of this was rat that the at 3 to the a in was also found not The was in to and The a 3 region methionine the region with a and with a that the a 1996; PubMed Scopus Google Scholar, 1999; PubMed Scopus Google Scholar). with this of rat with the region a major of the for of this region not are three of the methionine at these of translation at this 1996; PubMed Scopus Google Scholar). and were an in and translation system and a that only the first of 3 The first methionine in this is the of the cDNA and to in The at this putative is which is an for of translation the of a at 1996; PubMed Scopus Google Scholar, 1999; PubMed Scopus Google Scholar). at and the was also and of of translation at yield a protein of with a protein of was expressed was 3 this the with the was the lacking the that an methionine in Kalirin-7 as an in the of this The protein by the Kalirin the Sec14p-like domain and the first four spectrin-like repeats of Kalirin-7 3 of rat domain identified several proteins much Kalirin-7 Kalirin-8 P. Johnson R.C. Alam M.R. V. Mains R.E. Eipper B.A. J. Biol. Chem. 2000; Full Text Full Text PDF PubMed Scopus (113) Google Scholar). and are to Kalirin-7 and are because include additional COOH-terminal domains A. C. K. S. S. A. 1996; PubMed Scopus Google Scholar, R. Zheng H. S. J. 1998; Full Text Full Text PDF PubMed Scopus Google Scholar). Kalirin transcripts of and were identified with cDNA to the spectrin-like the DH-PH the COOH of Kalirin-8 the of these was a the SH3 domain of Kalirin-8 was to the Kalirin in the the abundant Kalirin-7 and a was cDNA Kalirin-8 at another of and of was found that not Kalirin-8 When the was as a a major at as as at and were the major form has been Kalirin-9 The protein by the Kalirin-9 a DH domain with an PH domain the first DH and PH domains When a was to a major of and were as as as at and only the transcripts at and to the a is also in that a truncated form of this protein only the domain of Kalirin may be expressed in and Kalirin transcripts and proteins were for forms of H. S. 1999; PubMed Scopus Google Scholar) identified a protein DH and PH domains and a protein domain of to the and domains of Kalirin-9 demonstrated a of Kalirin-9 to is at the to The protein domain of also a of homology to the protein domain of that one of the Kalirin transcripts a form of Kalirin a domain to the domain of By a Kalirin of the region of homology with and an the of a was When this was found to the Kalirin and domains with a putative protein domain. NH2 terminus, is to this form of rat with a domain a major as as of and also to specific for spectrin domains and COOH terminus, and protein has been Kalirin-12 and contains a Sec14p-like nine spectrin-like DH-PH an SH3 and a putative protein domain that the domain not a of the for H. S. 1999; PubMed Scopus Google in adult different Kalirin NH2 termini have been identified The a forms are the of P-CIP10a and The rat form to NH2 of the that are at three Kalirin to that Kalirin-7 of these at the of P. Johnson R.C. Alam M.R. V. Mains R.E. Eipper B.A. J. Biol. Chem. 2000; Full Text Full Text PDF PubMed Scopus (113) Google Scholar). which of these were in the of and was specific for and specific for the of the was of the putative domain to the length of the to be cDNA was all and were and to for three be for and Kalirin-8 transcripts the be Kalirin-8 transcripts the a were and of of that the a pair the pair the a yet the of generated this in is is that Kalirin transcripts have the a with specific for Kalirin-9 Kalirin-12 the of the major transcripts identified by patterns were to that with a in which the a truncated that these transcripts in in have the identified in the of these was specific for and a specific for the of the of the were by all four of with the that the transcripts have the for with the Kalirin region the the an to the of the growing of Kalirin transcripts the truncated have been as be and the forms in be and the functional of the many Kalirin transcripts specific for the COOH termini of and Kalirin-12 were generated an specific for the SH3 which Kalirin-9 and Kalirin-12 not Kalirin-7 The antisera generated all forms of Kalirin Kalirin proteins were of rat and a were by and proteins were with Kalirin antisera The Kalirin proteins with of and the most prevalent Kalirin protein a of and was identified as Kalirin-7 P. Johnson R.C. Alam M.R. V. Mains R.E. Eipper B.A. J. Biol. Chem. 2000; Full Text Full Text PDF PubMed Scopus (113) Google Scholar). the Kalirin forms by the in the were the forms in the to the Kalirin-7 the specific for the COOH of Kalirin-7 a protein of the protein by the transcripts were prevalent Kalirin-7 the protein was less prevalent. The major proteins by the specific for the SH3 domain to the and proteins by the The to the COOH of Kalirin-9 a major as The specific for the COOH of Kalirin-12 a major protein as the COOH of Kalirin-9 contains only and a was to the Kalirin-9 the at is to of the with common to of by the various antisera and proteins generated by of not be identified by this antisera were for and The nervous system not of all forms of Kalirin the cortex, Kalirin-7 is the major and is By in the olfactory and are the of protein the is much less Kalirin in the and the is yet another of proteins. The and Kalirin-12 antisera were to the of these major Kalirin proteins in of neurons. Kalirin-7 was localized to processes By Kalirin-9 was in and in the with the Kalirin-9 was the processes the with to Kalirin-12 was processes and was found in were with many neurons a of in the The Kalirin transcripts identified to through the use of five different 5′-ends, four different and of The of the has been R. Zheng H. S. J. 1998; Full Text Full Text PDF PubMed Scopus Google Scholar). of the of rat Kalirin and that several of the the Kalirin be with in of with be by the most prevalent are with with the these three are of The of and not significant homology to in the The lacking the Sec14p-like are of of these transcripts at a at the of the 5th spectrin-like repeat. of was of of The be in the of are 1996; PubMed Scopus Google Scholar, 1999; PubMed Scopus Google Scholar). of the forms is to be of functional The region of Kalirin the spectrin-like repeats the interacting of a domain (11.Aravind L. 1999; Full Text Full Text PDF PubMed Google Scholar). By the binding of Kalirin to the Sec14p-like domain to Rho family region of Kalirin and regions of Dbl and the of proteins K. Y. 1999; PubMed Scopus Google Scholar). was identified as an iNOS interactor in a (8.Ratovitski E.A. Alam M.R. Quick R.A. McMillan A. Bao C. Hand T.A. Johnson R.C. Mains R.E. Eipper B.A. Lowenstein C.J. J. Biol. Chem. 1999; 274: 993-999Abstract Full Text Full Text PDF PubMed Scopus (104) Google that iNOS also with forms of The most to Kalirin also yield and to Kalirin-12 and the DH-PH domain with the and domains R. Zheng H. S. J. 1998; Full Text Full Text PDF PubMed Scopus Google Scholar). of have been differ in the region the PH domain and of a expressed Dbl family is also NH2- and COOH-terminal regions with distinct functional domains P. Y. Oncogene. 1999; PubMed Scopus Google Scholar). the of the domain of Kalirin and A. C. K. S. S. A. 1996; PubMed Scopus Google Scholar) be to be NH2- to COOH-terminal and a C. protein that a role in all the protein domain R. Zheng H. S. J. 1998; Full Text Full Text PDF PubMed Scopus Google Scholar). the adult of Kalirin is to the nervous system (9.Alam M.R. Johnson R.C. Darlington D.N. Hand T.A. Mains R.E. Eipper B.A. J. Biol. Chem. 1997; 272: 12667-12675Abstract Full Text Full Text PDF PubMed Scopus (113) Google of is A. C. K. S. S. A. 1996; PubMed Scopus Google Scholar). the only of the family identified in C. is expressed in the with growing in and R. Zheng H. S. J. 1998; Full Text Full Text PDF PubMed Scopus Google Scholar). The DH domains of rat and Kalirin differ at only of the DH domain of Kalirin is most to the DH domains of and The homology of the first and DH domains of Kalirin is to the homology of Kalirin to Dbl to the DH domain of Kalirin is to GDP/GTP exchange A. C. K. S. S. A. 1996; PubMed Scopus Google Scholar). The COOH-terminal domain of Kalirin has the common to protein most protein the for the and has the Scholar, at Scholar). The domains of rat and Kalirin are the domains of rat Kalirin and are was in an in has been identified H. S. 1999; PubMed Scopus Google Scholar). The domain of has not yet been to have A. C. K. S. S. A. 1996; PubMed Scopus Google Scholar, S. A. N. A. Oncogene. 1998; PubMed Scopus Google Scholar). the domain of Kalirin as as that of another B.D. Darlington D.N. P. Johnson R.C. Eipper B.A. Mains R.E. J. Biol. Chem. 1999; 274: Full Text Full Text PDF PubMed Scopus Google of the may be The protein the homology to Kalirin are the protein and the chain protein was identified as a of by H. A. Scopus Google is to that of a of Kalirin the of secretion tumor cells (8.Ratovitski E.A. Alam M.R. Quick R.A. McMillan A. Bao C. Hand T.A. Johnson R.C. Mains R.E. Eipper B.A. Lowenstein C.J. J. Biol. Chem. 1999; 274: 993-999Abstract Full Text Full Text PDF PubMed Scopus (104) Google Scholar). chain is a protein that to J.K. J. G. 1998; PubMed Scopus Google Scholar). of the domains identified in Kalirin may to with proteins. The PH domains of rat and Kalirin are Kalirin is to and to the first PH domains of Kalirin and the PH domain of and the PH domains of PH domains have been in binding to to the of and to and are to the normal of Dbl family members (1.Cerione R.A. Zheng Y. Curr. Opin Cell Biol. 1996; 8: 216-222Crossref PubMed Scopus (466) Google Scholar, G. 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S. 1999; PubMed Scopus Google Scholar). with that a a in the protein have a of and be by the protein of this was that Kalirin is expressed in many and a protein may be identified. of a protein may of this of and that the in is to rat not the functions of is to in to the with which have been for many of the domains found in The Sec14p-like domain 3 1998; PubMed Scopus (231) Google Scholar). The of spectrin-like be long Y. A. PubMed Scopus Google Scholar). The first DH-PH domain of is long H. A. E.A. 1998; Full Text Full Text PDF PubMed Scopus Google Scholar). SH3 motif is another 3 The repeats 1999; PubMed Scopus Google Scholar). The protein domain form an in length J. J. PubMed Scopus Google Scholar). in a the length by one Kalirin The for are in and a is in Kalirin is large that one of functions may be functions be much as spectrin and in Curr. Cell Biol. 1998; PubMed Scopus Google Scholar, E.A. Cell Biol. 1998; 8: Full Text PDF PubMed Scopus Google Scholar, Y. P. S. 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Opin Cell Biol. 1996; 8: 216-222Crossref PubMed Scopus (466) Google Scholar). to the functions of Kalirin be of and many The different of and Kalirin-12 in neurons different for through several domains and protein and interacting may in the and the with in the of the A. G. J. Biol. Chem. 1999; 274: Full Text Full Text PDF PubMed Scopus Google Scholar). for of the to for of and and for
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