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The aim of the study was to investigate the protective and effects of Polygonum cognatum Meissn (PC) in treatment of colitis. Rats were orogastrically treated with (2g/kg) throughout a 10-day interval before and/or after , which was induced by intracolonic administration of acid. Microscopic damage scores and scanning electron changes of colon segments were analyzed. The of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in serum, malonyldialdehyde (MDA), glutathione (GSH), tissue factor (TF) levels, myeloperoxidase (MPO), dismutase (SOD), catalase (CAT) and (GGT) activities in the colon were measured. PC treatment ameliorated the acetic -induced disturbances in colonic tissue. Serum IL-6 and -α levels decreased with PC treated colitis group. tissue GGT, MPO activities and MDA levels were on the other hand SOD, CAT activities and GSH were increased in PC treated colitis group. PC was in the treatment of acetic acid-induced colitis in . This may be due to the supression and down regulation mediators in intestinal inflammatory response and the of antioxidant and anti-inflammatory response. conclusion, PC can play an protective role by the colonic tissue damage and oxidative which may be related to modulating the activities of molecules in rat model of colitis.
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Özge Çevik (2014) studied this question.
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