The induction in rat liver of a specific variant(s) of cytochrome P450 (PB‐P450) by phenobarbital and its repression by β‐naphthoflavone occur through corresponding changes in the levels of mRNA coding for the protein(s). The level of translatable mRNA coding for NADPH‐cytochrome P450 reductase in rat liver increases on treatment with phenobarbital but not β‐naphthoflavone.
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Shephard et al. (1982) studied this question.
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