= 270 nm) and Fourier-transform infrared spectroscopic analysis. Graphene nanoflakes were tested as a sole matrix and co-matrix with traditional MALDI-MS matrices for the lipid extracts obtained from normal breast, cancer and cancer stem cells with four different spotting methods. In all the cases, the graphene nanoflakes displayed a noise free and good quality mass spectrum. This study reveals the possibility that lipids could self-assemble as a multi-layered structure on the graphene nanoflake platform by electrostatic interactions between the graphene nanoflakes and the lipid head groups and thus result in noise-free spectra from GALDI-MS based lipidomics.
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Hua et al. (2014) studied this question.
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