January 1, 1997Ophthalmic Epidemiology
Effects of randomizing second eyes in a trial to evaluate preoperative medical testing for cataract surgery
Why the study?
Does routine preoperative testing prior to cataract surgery reduce major medical events within seven days following surgery?
Population
Patients undergoing cataract surgery
Comparison
Routine preoperative testing prior to cataract… vs No routine preoperative testing (untested group)
Design
Other, Rerandomization of second eye surgeries
Follow-up
7 days
Authors
Discussion
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Member takes
Implication
Rerandomizing eligible second-eye surgeries augments sample size with minimal power loss; leaves open whether preoperative testing reduces early medical events after cataract surgery.
Structured PICO
Does routine preoperative testing prior to cataract surgery reduce major medical events within seven days following surgery?
P
Population
Patients undergoing cataract surgery (estimated 20,000 surgeries needed to detect a 0.8% difference in rare major medical events)
I
Intervention
Routine preoperative testing prior to cataract surgery
C
Comparator
No routine preoperative testing (untested group)
O
Outcome
Major medical events occurring within seven days following surgerysafety
Rerandomizing second eye surgeries (if >28 days after the first) in cataract surgery trials allows for increased sample size with minimal impact on statistical power.
Cite This Study
Katz et al. (1997) studied this question.