Essential Macroglobulinemia

Case Studies1 May 1965Essential MacroglobulinemiaReport of a Case Including Immunofluorescent and Electron Microscopic StudiesHAROLD J. WANEBO, M.D., BAYARD D. CLARKSON, M.D.HAROLD J. WANEBO, M.D.Search for more papers by this author, BAYARD D. CLARKSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1025 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEssential or "Waldenström's" macroglobulinemia was first described by Waldenström (1) in 1944, and since then it has been reported with increasing frequency (2-6). It is a disease characterized by abnormal proliferation of cells that are generally described as atypical lymphoid cells and the presence in the serum of a high molecular weight globulinthat is quite homogeneous on electrophoresis. This paper describes a patient with the characteristic findings of Waldenström's macroglobulinemia in whom macroglobulin was demonstrated in the cytoplasm of certain cells in the spleen by immunofluorescent techniques; these studies were correlated with the morphologic appearance of the cells when...References1. WALDENSTRÖM J: Incipient myelomatosis or "essential" hyperglobulinemia with fibrogenopenia—a new syndrome? Acta Med. Scand. 117: 216, 1944. CrossrefGoogle Scholar2. WALDENSTRÖM J: Diseases associated with abnormal plasma proteins. Proc. Roy. Soc. Med. 53: 789, 1960. CrossrefMedlineGoogle Scholar3. RITZMANNTHURMTRUAXLEVIN SERHWEWC: The syndrome of macroglobulinemia. Arch. Intern. Med. (Chicago) 105: 939, 1960. CrossrefMedlineGoogle Scholar4. MARTIN NH: Macroglobulinaemia: a clinical and pathological study. Quart. J. Med. (new series) 29: 179, 1960. MedlineGoogle Scholar5. FESSEL WJ: Clinical analysis of 142 cases with high molecular weight serum proteins. Acta Med. Scand. 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CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New YorkFrom the Division of Clinical Chemotherapy, Sloan-Kettering Institute for Cancer Research, the Departments of Medicine, Memorial Hospital for Cancer and Allied Diseases and James Ewing Hospital, and the Sloan-Kettering Division of the Graduate School of Medical Sciences, Cornell University Medical College, New York, N. Y.This investigation was supported in part by research grant CA-03215 from the National Institutes of Health, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to Dr. Bayard Clarkson, Sloan-Kettering Institute for Cancer Research, 425 E. 68th Street, New York, N. Y. 10021. 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