Why the study?
Does species-specific Brain natriuretic peptide (BNP) testing have diagnostic potential for cardiac dysfunction in dogs?
Does species-specific Brain natriuretic peptide (BNP) testing have diagnostic potential for cardiac dysfunction in dogs?
The development of a species-specific BNP test for dogs could enable its use as a screening tool for cardiac dysfunction in veterinary clinical practice.
The endocrine role of the heart is evident in the secretion of noradrenaline and natriuretic peptides. The secretion of natriuretic peptides presents a useful mechanism for different conditions of cardiac dysfunction. Brain natriuretic peptide (BNP) has been accepted in human cardiology as a biomarker for cardiac insufficiency and coronary arterial disease. The specificity of the BNP structure is specie-specific, so that the testing of diagnostic and prognostic potential in dogs requires the existence of a test that is a homologue for that animal specie. The existence of an adequate method for measuring BNP concentration makes possible its implementation as a screening test in everyday clinical practice. .
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Ljubica Spasojević-Kosić (2009) studied this question.
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