The multitalented catalyst 1/Ni(ClO4)2 mediates both title processes (see scheme). Together the efficient asymmetric cycloaddition and a kinetic resolution/cycloaddition provide access to both enantiomers of tetrahydro-1,2-oxazines. DME=1,2-dimethoxyethane; R1=aryl, vinyl; R2=Et, Me, benzyl; R3=Me, Ph; R4=aryl, styryl.
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Kang et al. (2007) studied this question.
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