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January 1, 2012journal of Diabetes Research and Clinical MetabolismOpen Access

Copper is a potent inhibitor of the propensity for human ProIAPP1-48 to form amyloid fibrils in vitro

Christopher Exley Matthew Mold Emma Shardlow Benjamin Shuker Baritore Ikpe Ling Wu Paul E. Fraser

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Abstract

Background: The amyloidogenic peptides IAPP and ProIAPP1-48 are implicated in β cell death in type 2 diabetes mellitus. While the mechanism of their deposition in vivo is unknown we have shown

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Exley et al. (2012) studied this question.

synapsesocial.com/papers/6a8bdbae60c8c47a9ee3edba https://doi.org/10.7243/2050-0866-1-3

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Processing of Pro-Islet Amyloid Polypeptide in the Constitutive and Regulated Secretory Pathways of β CellsOriginal Research · 2005 · 74 citations
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