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Upon entering the E. coli cell, T2 DNA causes the formation of phage-specific messenger RNA. Base composition similarities (Volkin and Astrachan, 1956) suggest that the RNA structure is specified by base-pair hydrogen bonding between precursor ribonucleotides and the DNA template. Because complex formation between T2 DNA and T2 messenger RNA (Hall and Spiegelman, 1961) is based upon similar base-pair interactions, it provides a useful tool for studying the relation of RNA copy to DNA template.
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Hall et al. (1963) studied this question.
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