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There is increasing enthusiasm regarding the use of bio-banked whole blood DNA as a model to discover methylation marks associated with biological phenotypes and generate novel mechanistic hypotheses (1–3). DNA methylation has a critical role in cell functions and is cell-type specific. Such cell specificity makes DNA methylation particularly challenging for epidemiological epigenetic investigations because disease relevant cell types might not be accessible due to practical issues such as availability, ethics, and cost associated with more complex specimen collection.
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Gagnon et al. (2014) studied this question.
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