Recommendations included a systematic review of published English language literature from publication of previous British Society for Haematology (BSH) Management of Chronic Lymphocytic Leukaemia Guidelines 2012) up to 03/2021.In addition, there are some additional pertinent references and a consensus of expert opinion where no published data are available.PubMed, MEDLINE, EMBASE, Cochrane databases and Web of Science were searched using the preliminary search terms; chronic lymphocytic leukaemia OR CLL AND Richter's transformation OR Richter's syndrome OR transformed/developed/progressed to aggressive lymphoma/high-grade lymphoma/DLBCL/Hodgkin lymphoma.Systematic reviews,including guidelines from other countries, prospective clinical trials, observational studies i.e., cohort or case-control studies, expert reviews and opinions and case series were considered and reviewed as appropriate.
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