Obesity is associated with a chronic low-grade systemic inflammatory response, characterized by increased secretion of adipokines such as TNF-α, IL-6, and CRP.
Does not yet guide clinical obesity care; leaves open whether adipokine-targeted therapies improve cardiovascular outcomes.
besity is known to be a contributing factor through inflammatory mediators to a wide array of disease, ranging from decreased life expectancy to cardiac disease, diabetes, and metabolic syndrome (MS). The chronic low-grade systemic inflammatory response is a major health concern in the life of obese patients. Adipose tissue is responsible for the secretion of cytokines, also known as adipokines, including tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). The c-reactive protein (CRP) is another adipokine associated with obesity. Several studies have found that the inflammation present in obesity is associated with a significantly increased CRP level in obese people compared to non-obese people.
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Mazloom et al. (2009) studied this question.
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