Why the study?
Does chronic HCV infection alter the PAF/pPAF-AH system, and does antiviral treatment restore it?
Does chronic HCV infection alter the PAF/pPAF-AH system, and does antiviral treatment restore it?
Chronic HCV infection is associated with increased PAF levels and decreased pPAF-AH activity, which are restored upon viral clearance, suggesting a role for the PAF system in HCV-related damage.
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HCV-associated PAF elevation and reduced pPAF-AH activity normalized after clearance; hypothesis-generating for PAF pathway role in HCV damage, needs prospective confirmation.
Caini et al. (2006) studied this question.
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