Inhibition of the Lymphocytolytic Activity ofCortisol by Total Hepatectomy1

The lymphocytolytic effect of cortisol was assessed in totally hepatectomized- adrenalectomized rats in order to evaluate a possible role of the liver in lymphocytolysis induced by cortisol. Blood lymphocyte values and lymphoid tissue weights were determined following steroid administration in laparotomized animals, and in animals subjected to either partial or total evisceration. Cortisol elicited a marked lymphopenia and diminution of thymus and lymph node weights in laparotomized or partially eviscerated rats with their liver and kidneys in situ. Following total removal of the liver, however, cortisol, injected subcutaneously or intravenously, failed to induce the usual lymphopenic response. In addition, no involution of lymph nodes was observed in these animals; depression of thymus weight did occur but was significantly less than that found with animals whose abdominal viscera were removed except for the liver and kidneys. These results suggest that the liver plays a significant role in the manifestation of the lymphocytolytic effect of adrenal cortical steroids.(Endocrinology77: 574,1965)