Case report reveals fatal central nervous system hemophagocytic lymphohistiocytosis in an infant with dengue, highlighting the urgency of recognizing subtle neurological signs.
Key Points
To report a novel presentation of central nervous system hemophagocytic lymphohistiocytosis triggered by severe dengue infection in an infant.
Assessed an eight-month-old male infant admitted with febrile illness, hepatosplenomegaly, and hematochezia.
Performed diagnostic workup including dengue NS1 antigen testing, coagulation profiles, serum ferritin, brain MRI, and cerebrospinal fluid analysis.
Treated with supportive care, systemic dexamethasone, intrathecal methotrexate and hydrocortisone, and intravenous etoposide.