Polymorphism of IgG Fc Receptors in Meningococcal Disease

Letters1 October 1993Polymorphism of IgG Fc Receptors in Meningococcal DiseaseCees A. P. Fijen, MD, Robert G. M. Bredius, MD, and Ed J. Kuijper, MDCees A. P. Fijen, MD, Robert G. M. Bredius, MD, and Ed J. Kuijper, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-7_Part_1-199310010-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In defending against meningococci, specific antibodies and an intact complement system are essential [1, 2]. Immunity to meningococcal disease may also be determined by the interaction between IgG and the IgG Fc receptor (Fc R) on polymorphonuclear cells. We hypothesized that particular combinations of Fc R allotypes may determine the susceptibility to meningococcal disease, especially in persons who lack serum bactericidal activity because of deficiency of a component in the terminal pathway of complement activation. Of the three classes of Fc R that have been identified, only the Fc RIIa (CD32) and Fc IIIb (CD16) are constitutively ...References1. Goldschneider I, Gotschlich EC, Artenstein MS. Human immunity to the meningococcus. J Exp Med. 1969; 129:1307-48. Google Scholar2. Figueroa JE, Densen P. Infectious disease associated with complement deficiencies. Clin Microbiol Rev. 1991; 4:359-95. Google Scholar3. Van de Winkel JG, Anderson CL. Biology of human immunoglobulin G Fc receptors. J Leuko Biol. 1991; 49:511-24. Google Scholar4. Warmerdam PA, van de Winkel JG, Vlug A, Westerdaal NA, Capel PJ. A single amino acid in the second Ig-like domain of the human Fc receptor II is critical for human IgG2 binding. J Immunol. 1991; 147:1338-43. Google Scholar5. Salmon JE, Edberg JC, Brogle NL, Kimberly RP. Allelic polymorphisms of human Fc receptor IIA and Fc RIIIB. J Clin Invest. 1992; 89:1274-81. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIncreased risk of thrombosis in FcγRIIA 131RR patients with HIT due to defective control of platelet activation by plasma IgG2Genetic Polymorphisms in Critical Illness and InjuryThe FcγR of Humans and Non-human Primates and Their Interaction with IgG: Implications for Induction of Inflammation, Resistance to Infection and the Use of Therapeutic Monoclonal AntibodiesThe Role of IgG in Immune ResponsesInfections in Patients with Hematologic Malignancies Treated with Monoclonal Antineoplastic TherapySepsisAnalysis of MIF, FCGR2A and FCGR3A gene polymorphisms with susceptibility to pulmonary tuberculosis in Moroccan populationGenetic Polymorphisms in Critical Care and IllnessGenetic approach to pediatric septic shockHost Genetic Susceptibility to InfectionDengue and dengue haemorrhagic fever: implications of host geneticsDistribution of FcγRIIa and FcγRIIIb Genotypes in Patients With Generalized Aggressive PeriodontitisGenetic polymorphisms in sepsisGenetische factoren van de gastheer in infecties met Neisseria meningitidisThe Last of the Meningococcus?Association of the Fcγ receptor IIA-R/R131 genotype with myasthenia gravis in Dutch patientsHost genetic determinants of Neisseria meningitidis infectionsFcγR polymorphisms: Implications for function, disease susceptibility and immunotherapyThe Fcγ Receptor Genotype as a Severity Factor for Chronic Periodontitis in Japanese PatientsFcγ receptors in autoimmune diseasesCellular and humoral defence mechanisms against bacteriaEvaluation of Human FcγRIIA (CD32) and FcγRIIIB (CD16) Polymorphisms in Caucasians and African-Americans Using Salivary DNANeutrophil Fc γ RIIIb allelic polymorphism in anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitisAssociation Between FcγRIIa-R131 Allotype and Bacteremic Pneumococcal PneumoniaProperdin deficiency and meningococcal disease-identifying those most at riskNo association between neutrophil FcγRIIa allelic polymorphism and anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitisHost genes and infectious diseasesFcγ Receptor PolymorphismsTFc?RIIIA-158F allele is a risk factor for systemic lupus erythematosusSerum IgG2 level, Gm(23) allotype and FcgammaRIIa and FcgammaRIIIb receptors in refractory periodontal diseaseClinical Value of Soluble IgG Fc Receptor Type III in Plasma From Patients With Chronic Idiopathic NeutropeniaComplement Deficiencies and InfectionFcγ receptor polymorphisms: clinical aspectsMeningococcal disease and polymorphism of FcγRIIa (CD32) in late complement component-deficient individualsSaliva: a convenient source of DNA for analysis of bi-allelic polymorphisms of Fcγ receptor IIA (CD32) and Fcγ receptor IIIB (CD16)FcγRIIa Polymorphism in Human Immunodeficiency Virus-Infected Children with Invasive Pneumococcal DiseaseVaccine-Induced IgG Antibodies to the Linear Epitope on the PorB Outer Membrane Protein Promote Opsonophagocytosis ofNeisseria meningitidisby Human NeutrophilsFcγriia polymorphism as a risk factor for invasive pneumococcal infections in systemic lupus erythematosusClinical Relevance of Fc? 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