IN manometric measurements of tissue metabolism in serum or similar fluids the problem of allowing for the C02-combining properties of the medium is constantly arising. On the one hand the increase of CO2 tension due to re- spiration leads to a portion of the extra CO2 being bound by salts of weak acids (BP), including particularly the alkali proteinates, of the serum according to the equation: BP+H2CO3=BHCO3+ HP ...... (1).
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Dickens et al. (1932) studied this question.
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