Synergistic Interactions of Antimicrobials to Counteract the Drug-Resistant Microorganisms

The development of multiple drug resistance organisms (MDR) is a major threat, and due to this emergence, it is found that it is difficult to treat many infectious diseases. Synergistic interaction means combining existing antimicrobials with any component that says it can be a herbal compound, phytochemicals, essential oils, antibiotics, antimicrobial peptides, and even any other antimicrobial. With the help of antimicrobial and phytochemical blending, this effective resistance conversion will neutralize the resistance mechanism, which makes the drug effective in resistant organisms. Microbes have developed several strategies, such as efflux pump inhibitors or inhibition of drug degrading enzymes. This combination interaction has shown promising abatement in minimum inhibitory concentrations and upturn of susceptibility of drug-resistant microorganisms. This synergistic interaction is brought into play because it is very difficult to develop new antimicrobials. There are already only limited antimicrobials that are segregated into classes and cannot be used all the time. So this synergistic effect can bring about a change like it can be used to increase antimicrobials' effect and prevent resistance in the organisms. Thus, it might be helpful in the effective treatment against various infections.