Drug sensitivity of an adriamycin-resistant mutant subline of mouse lymphoblastoma L5178Y cells.

Anthracycline-resistant sublines have been isolated in a number of cell lines and cross-resistance with actinomycin, vinca alkaloids and other inhibitors have been demonstrated. Drug resistance has been suggested to be due to alteration of the cell membrane, resulting in permeability barriers to drugs, or to impaired retention of antibiotics.1-6)