This case indicates that synergism may occur between lithium and spironolactone, which might be clinically useful in patients resistant to lithium or in whom low dose lithium is advisable. Moreover, this case also indicates that spironolactone alone may maintain a manic patient in remission. Further research is needed to assess the mode of action of spironolactone alone or in combination with lithium in the treatment of mania.
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Ahlbom et al. (1986) studied this question.
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