Comparing the effects of nettle extract with combined oral contraceptives on improving clinical and paraclinical symptoms of polycystic Ovary Syndrome: A triple-blind randomized controlled clinical trial

What is current knowledge?Nettle (Urtica dioica) possesses several medicinal properties, including antioxidant, anti-inflammatory, anti-ulcer, anticancer, and antibacterial and antifungal effects.Additionally, it may contribute to the improvement of clinical and paraclinical symptoms associated with Polycystic Ovary Syndrome (PCOS). What is new here?The findings indicate that nettle extract is effective in reducing levels of dehydroepiandrosterone, total testosterone, folliclestimulating hormone (FSH), and luteinizing hormone (LH).Moreover, it significantly decreases hirsutism scores and the duration of menstrual bleeding.