Why the study?
Are plasma levels of brain natriuretic peptide elevated in patients with acute hypoxaemic chronic obstructive pulmonary disease compared to healthy controls?
Population
12 patients admitted with acute hypoxaemic chronic obstructive pulmonary disease (9 with oedema on admission)
Design
Case-control
Authors
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Elevated BNP in hypoxemic COPD is hypothesis-generating; leaves open any role in risk stratification or targeted therapy pending prospective validation.
Are plasma levels of brain natriuretic peptide elevated in patients with acute hypoxaemic chronic obstructive pulmonary disease compared to healthy controls?
Plasma levels of BNP are significantly elevated in acute hypoxaemic COPD and correlate with the degree of hypoxaemia, suggesting a potential role in pulmonary vasoregulation or right ventricular strain.
Lang et al. (1992) studied this question.