Answers are grounded in this paper and cite their sources.
The interaction of ketoprofen with tri-O-methyl-β-cyclodextrin (methyl-β-CD) was investigated in vitro and in vivo. The phase solubility diagram revealed a linear relationship (AL type), and the solubility of ketoprofen in 0.1 M methyl-β-CD aqueous solution was 20 times that in pure water. The bioavailability of ketoprofen following oral administration with methyl-β-CD to rats was 3.7 times that of ketoprofen alone.
No takes yet. Share an insight, caveat, or question.
Nakai et al. (1983) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: