Studies on active substances in the herbs used for Oketsu ("stagnant blood") in Chinese medicine. III. On the anticoagulative principles in curcumae rhizoma.

The anticoagulative principles were isolated from Curcumae Rhizoma by a combination of partition and column chromatographies on silica gel, and identified as 1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-dione (curcumin), p, p'-dihydroxydicinnamoylmethane and p-hydroxycinnamoylferuloylmethane. During the isolation process plasma recalcification time in mice was used to follow the anticoagulative activity of the material.