Experimental study demonstrates multicomponent synthesis of stable functionalized imidazole-2-selones using elemental selenium, highlighting versatile reactivity for organoselenium chemistry.
We have developed a multicomponent synthesis of a new family of stable selones, 3-acylarylethenyl-1-alkylimidazole-2-selones, in 28–86% yields by intercepting (MeCN, 70 °C) N-alkyl-N-alkenylimidazolium carbenes, generated in situ from substituted imidazoles and acylarylacetylenes, with elemental selenium. The basic reactivity (E/Z-photoisomerization, reduction, hydrolysis/oxidation, and oximation) of the synthesized imidazole-2-selones has been evaluated.
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Belyaeva et al. (2026) studied this question.
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